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On January 1, 2018, United Continental Holdings, Inc. ("UAL") adopted Accounting Standards Update No. 2014-09 (Topic 606), Revenue from Contracts with Customers , and Accounting Standards Update No. 2017-07, Improving the Presentation of Net Periodic Pension Cost and Net Periodic Postretirement Benefit Cost . As such, certain previously reported 2017 figures are adjusted in this report on a basis consistent with the new standards. See the Current Report on Form 8-K filed by UAL with the Securities and Exchange Commission on March 1, 2018 for additional information.

SOURCE United Airlines

For futher information: United Airlines Worldwide Media Relations, +1-872-825-8640, media.relations@united.com

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July 13, 2018

LOS ANGELES, July 13, 2018 /PRNewswire/ -- Today, United Airlines announced a $1 million grant to First Place for Youth in support of their My First Place program. The four-year investment will enable First Place to expand wraparound support services to 50 percent more foster youth in the region. First Place will strengthen career-focused programming and provide the tools to help secure meaningful employment and increase lifetime earning potential for Angeleno foster youth.

With this grant, First Place for Youth will dramatically expand its reach, moving more high-risk foster youth 16 to 24 years old from homelessness into safe, affordable apartments and giving them the skills they need to compete in the job market and to realize long-term self-sufficiency. The Los Angeles nonprofit will be able to enroll more young people in academically rigorous linked learning programs that result in industry-recognized certificates that can lead to a living-wage career.

"As California's global airline, United cares deeply about investing in the state's future," said United's President of California Janet Lamkin. "Los Angeles County is home to one-third of California's foster youth and we are proud to help First Place target growth in high-needs areas of the community, like South Los Angeles, and help ensure California's youth have increased access to high-quality programs that lead to employment in a wide variety of fields, including aviation."

"Everyone deserves access to the opportunity to earn a paycheck and succeed, especially our most vulnerable young people," said Los Angeles Mayor Eric Garcetti. "Through our HIRE LA's Youth program, partners like United Airlines and First Place For Youth are helping our young people find jobs, start careers, and realize their dreams."

Over the next four years, United's investment in the My First Place program will help First Place for Youth provide Los Angeles' foster youth with safe, stable housing, individualized education and employment counseling and healthy living support services. United will work hand-in-hand with the local organization and engage with city and community leadership to create profound, sustainable advancements for the city's foster youth population.

"We are so grateful for the incredible generosity of United Airlines as they expand their impact in Los Angeles. With this investment, First Place will support more than 650 young people who grew up in foster care, helping them move into their first apartment, make progress in school, and secure jobs that lead to living-wage careers. We believe that all young people deserve the opportunity to achieve their full potential in life," said Hellen Hong, Interim CEO and Chief Regional Office at First Place for Youth.

Today's announcement is the fifth in a series of announcements United is making in all of its domestic hub markets over the coming weeks. Each grant is a part of a total of $8 million in grants to help address critical needs identified by local leadership in each of its hub market communities – Chicago, Denver, Houston, Los Angeles, San Francisco, Newark/New York and Washington, D.C. The announcement represents United's commitment to invest in and lift up the communities where many of its customers and employees live and work.

About United

United Airlines and United Express operate approximately 4,600 flights a day to 357 airports across five continents. In 2017, United and United Express operated more than 1.6 million flights carrying more than 148 million customers. United is proud to have the world's most comprehensive route network, including U.S. mainland hubs in Chicago, Denver, Houston, Los Angeles, Newark/New York, San Francisco and Washington, D.C. United operates 757 mainline aircraft and the airline's United Express carriers operate 551 regional aircraft. The airline is a founding member of Star Alliance, which provides service to 193 countries via 28 member airlines. For more information, visit united.com, follow @United on Twitter or connect on Facebook. The common stock of United's parent, United Continental Holdings, Inc., is traded on the NYSE under the symbol "UAL".

About First Place For Youth

First Place for Youth serves nearly 2,000 foster youth, ages 16-24, across California each year and is the state's largest provider of housing and support services for this vulnerable population. Program participants receive safe, stable housing, individualized education and employment counseling, and healthy living support services so that they can build the skills necessary to make a successful transition to adulthood. Headquartered in Oakland, CA, First Place operates its Southern California regional office in Los Angeles, and county offices in Contra Costa, San Francisco, Santa Clara, and Solano, as well as through affiliate partnerships in Boston, MA and the state of Mississippi. Since 1998, First Place has supported more than 10,000 foster kids in beating the odds and proving that more is possible. For more information, visit firstplaceforyouth.com, follow @FPFY on Twitter, or connect on Facebook.

SOURCE United Airlines

For futher information: United Airlines Worldwide Media Relations, +1-872-825-8640, media.relations@united.com

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July 12, 2018

CHICAGO, July 12, 2018 /PRNewswire/ -- Today, United Airlines (UAL) announced the redesigned united.com homepage, featuring a more personalized digital experience for each customer and an updated, more modern, user-friendly design. The new homepage was created to better tailor the experience for customers, while also improving functionality and ease of use.

Fig. 1.

v-Src expression leads to constitutive activation of wild-type and fluorescent STAT3 fusion proteins. (A) COS-7 cells were transiently transfected with v-Src and STAT3 as indicated and stimulated with 20 ng/ml IL-6 and 1 μg/ml sIL-6Rα for 30 minutes or left untreated. Whole cell lysates were subjected to SDS-PAGE and western blotting. STAT3 tyrosine phosphorylation was detected with a pY-STAT3 antibody and as a loading control STAT3 was counterstained with a specific STAT3 antibody. (B) Transiently expressed STAT3-YFP and mutant fusion proteins as indicated were precipitated from COS-7 cell lysates with a GFP antibody that recognizes YFP and CFP. Western blot analyses of precipitates were performed for pY-STAT3 and counterstained for total STAT3 and YFP. hc, heavy chain of the precipitating antibody. (C) Nuclear extracts were prepared from MEF, MEF or MEFSTAT3-YFP cells stimulated with 20 ng/ml IL-6 and 1 μg/ml sIL-6Rα for 30 minutes as indicated. STAT3, STAT1 and STAT3-YFP DNA-binding to a [P]-labelled SIE-probe was detected by EMSA. Antibodies against STAT3 and GFP were used for the supershift experiment. (D) MEFSTAT3-YFP cells were co-transfected with v-Src, fixed and stained for pY-Src. Fixed cells were analyzed by confocal laser-scanning microscopy. Bars, 10 μm. A Western blot of lysates of MEFSTAT3-YFP cells was analyzed for pY-STAT3 and counter-stained for total STAT3. (E) MEFSTAT3-CY cells were treated and analyzed as described in D. Bars, 10 μm. A Western blot of lysates of MEFSTAT3-CY cells was analyzed for pY-STAT3 and counter-stained for total STAT3. (F) MEF and MEFSTAT3-YFP cells were transfected with v-Src, Fyn, Abl, or BCR-Abl or left untransfected for IL-6 stimulation and the negative control as indicated. Whole cell lysates were subjected to western blotting and analyzed for pY-STAT3 and total STAT3 as a loading control.

Fig. 2.

Jak1, SOCS3 and PIAS3 in v-Src-mediated STAT3 activation. (A) Parental and Jak1-deficient human fibrosarcoma cells were transiently transfected with STAT3-YFP. Cells were stimulated with 20 ng/ml IL-6 and 1 μg/ml sIL-6Rα for 30 minutes (middle panel) or left unstimulated (upper panel). Cells transiently co-transfected with v-Src were left unstimulated (lower panel). Cells were fixed with paraformaldehyde and, as a nuclear marker, lamin A/C was stained. v-Src was stained with an antibody recognizing pY-Src. Cells were analyzed by confocal laser-scanning microscopy. Bars, 10 μm. (B) HepG2 human hepatocellular carcinoma cells were transiently transfected with v-Src or with an empty vector. A STAT3-responsive luciferase reporter gene construct under control of the α2M-promoter was co-transfected. Cells were incubated with 20 ng/ml IL-6 or left unstimulated for 24 hours in the presence or absence of 100 ng/ml Jak inhibitor 1 as indicated. Reporter gene assays were performed in triplicate and standard deviations were calculated. (C) HepG2 cells were transiently transfected with YFP-SOCS3 and STAT3-CFP (upper and middle panel) or with YFP-SOCS3, STAT3-CFP and v-Src (lower panel). Stimulation was performed with 20 ng/ml IL-6 for 30 minutes. Fixed cells were stained for lamin A/C or pY-Src, respectively. Images were taken by confocal laser-scanning microscopy. Bars, 10 μm. (D) HepG2 cells were transiently transfected with SOCS3, v-Src and a α2M reporter gene construct as indicated. Reporter gene assays of IL-6 stimulated (+) and unstimulated (–) cells were performed as described in B. (E) HepG2 cells were transiently transfected with FLAG-PIAS3 and STAT3-CFP (upper and middle panel) or with FLAG-PIAS3, STAT3-CFP and v-Src (lower panel). Stimulation was performed with 20 ng/ml IL-6 for 30 minutes. Fixed cells were stained for FLAG-tagged PIAS3 using a FLAG antibody and an antibody recognizing pY-Src, respectively. Cells were analyzed by confocal laser-scanning microscopy. Bars, 10 μm. (F) HepG2 cells were transiently transfected with v-Src, FLAG-PIAS3 and a α2M reporter gene construct as indicated. Reporter gene assays were performed as described in D.

STAT3 activation mediated by gp130 is highly sensitive to suppression by SOCS3 ( Schmitz et al., 2000 ). Therefore, co-transfection of STAT3-CFP and YFP-SOCS3 into HepG2 cells blocks IL-6-induced nuclear translocation of STAT3-CFP ( Fig. 2C , middle panel). By contrast, v-Src-mediated nuclear accumulation of STAT3-CFP is not affected by YFP-SOCS3 ( Fig. 2C , lower panel). This finding is supported by the results of a reporter gene assay showing that induction of the α2-macroglobulin promoter by v-Src in HepG2 cells is increased rather than inhibited by SOCS3 ( Cheap Sale Countdown Package Alexander McQueen Asym Ruff shirt Cheap Sale Get Authentic Sale Good Selling Shop Outlet Eastbay ZhjqXf
) whereas IL-6-induced α2-macroglobulin induction is strongly downregulated by SOCS3. Taken together, these data suggest that STAT activation through v-Src circumvents Jaks and thereby prevents inhibition by SOCS3.

Fig. 4.

A Poisson interval distribution for the return times of extreme events. (A) The Poisson probability density function. Note that intervals less than the mean are much more probable than intervals greater than the mean. (B) An example of Poisson-distributed events. Events, indicated by vertical lines, tend to occur in clusters.

As noted above, the Poisson interval distribution rests on the assumption that the probability of encountering an extreme event is small and constant: an assumption made likely by the manner in which extremes arise. Environmentally driven extreme events are often caused not by an excessive value of any single aspect of the physical environment (e.g. air temperature), but rather by the savage alignment of multiple factors that are individually benign ( Denny et al., 2009 ). Consequently, there is a low probability that the requisite values of all parameters will arrive in synchrony to generate extreme conditions. Indeed, estimated return times of extreme events in the rocky intertidal zone, which depend on the confluence of numerous environmental parameters (low tide, bright sun, low wind speed, no wave splash), conform well to the predictions of Eqn4 ( GVGV silver eyelet midwidth belt Fast Delivery For Sale 47P32
; Denny et al., 2009 ). Analogous mechanics apply in other aspects of environmental physiology, suggesting that a constant probability of extreme stress (and thereby a Poisson distribution of return times) may be common.

A useful tool in this context is the environmental bootstrap, which resamples relatively short time series (e.g. a 7-year time series of the environmental parameters that determine the body temperatures of intertidal organisms) to generate realistic hypothetical time series of any desired length. These time series allow one to estimate the probability of encountering extreme thermal events, which in turn allows the distribution of inter-event intervals to be calculated (see above). The details of the environmental bootstrap can be found in Denny et al. (2009) and we have recently reviewed the salient features of the approach ( Denny and Dowd, 2012 ).

The environmental bootstrap is particularly useful when combined with biophysical models that calculate time series of body temperatures based on the stochastically varying environmental conditions (an ecomechanical approach, Valentino Valentino Garavani Rockstud Indi messenger bag View Sale Finishline High Quality Buy Online FrWMnO
). For example, we used a 2000-year hypothetical time series of environmental conditions (data for every 10-min interval) generated by the environmental bootstrap as input to a species-specific heat-budget model to simulate the time course of body temperature in a population of intertidal limpets. From these data, we then modeled the effects of environmental stochasticity on the evolution of limpets' thermal tolerance ( Denny and Dowd, 2012 ). Our simulations suggest that this realistic, stochastic variation of limpet body temperature drives the evolution of a substantial ‘safety margin’, a difference of 5–7°C between the average lethal temperature in a population and the average annual maximum temperature. This predicted safety margin approximates the results of thermal tolerance studies on wild-caught limpets from our study site.

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Dozens of accident and emergency units are facing closure or being downgraded in a far-reaching overhaul of urgent care which senior doctors warn would have “disastrous” consequences for the NHS.

An analysis of documents drawn up to remodel the health service in England shows that 24 casualty units from Durham to Somerset have been marked for potential closure despite record demand for AEs and serious overcrowding across the country as the NHS goes through its most severe winter crisis since records began. Last month produced the worst performance for AE waits in 13 years.

175 emergency units

NHS bosses who have drawn up the changes as part of efforts to plug a £22bn hole in the health service budget by 2021, insist that concentration of specialist urgent services could save lives and there are no plans for a “significant” reduction in the existing number of 175 emergency units.

But one senior emergency doctor told i that the plans amount to proposal to “make the River Nile run backwards” by planning for a reduction in demand for AE services at a time when Britain has a growing and ageing population.

Research based on 44 regional blueprints by the Johnston Press Investigation Unit reveals that managers are planning to cater for up to 30 per cent fewer AE visits and plans have already been advanced to downgrade units to urgent care centres (UCC) with fewer specialist or consultant-grade staff.

In north east London, the King George Hospital will see its AE become a UCC by 2019. Similar plans are under consideration in Dewsbury, West Yorkshire, and Poole in Dorset. In Staffordshire, health bosses have set a goal of a 30 per cent reduction in AE visits; in Norfolk the figure is 20 per cent.

’15 per cent of all AEs face closure’

A separate study by the Health Service Journal (HSJ) has found that around 15 per cent of the total number of AEs face closure or downgrading with several areas facing “either/or” decisions between neighbouring units.

Under the five-year project to plug the hole in the NHS budget in England, Sustainability and Transformation Plans (STPs) have been drawn up for each of 44 “regions” to remodel services.

A key part of the scheme is to reduce reliance on hospitals, in particular AE units, by expanding primary care into integrated “hubs” staffed by GPs and other carers, bolstered by technology and teams to carry out home visits.

‘Wishful thinking and rhetoric’

But emergency medicine experts argue that the NHS lacks the additional beds and community care resources that would be required to cope with such a change. At a time when 12-hour trolley waits have doubled in the last two years, they accuse managers of basing the future of the health service on “wishful thinking and rhetoric”. According to leaked figures, some 780 people last month waited more than 12 hours for a bed while in AE – compared to 158 in January 2015.

Dr Chris Moulton, vice president of the Royal College of Emergency Medicine (RCEM), told i : “AE units are already desperately short of capacity and hospitals have almost 100 per cent bed occupancy. The suggestion that you can close AE departments and then somehow fewer people will become ill is clearly ridiculous. And anyway, it is not people with minor illnesses but elderly patients with serious conditions who are the ones lying on AE trolleys waiting for beds and then languishing on the wards awaiting social care.

“The problem is that the STPs are trying to design the health service around the fallacy that you can downgrade AE departments and then not provide comparable capacity elsewhere. They are predicting a pattern of falling demand when AE attendances have consistently risen for decades. There is no clear indication as to how this miracle might be achieved.”

He added: “We have a rapidly growing and ageing population and therefore the idea that the health service won’t have to deal with even higher numbers of people requiring emergency care and hospital admission in the future is like hoping that the River Nile will run backwards.”

Change

The professional body said that while it agreed that numerous units were facing change, it was only aware of five AEs at immediate risk. But it warned that a decision to implement 24 closures – equivalent to one in six of the total – was unthinkable.

The HSJ, which said it was aware seven closures or downgrades already in the pipeline, found that 26 hospitals were involved in “head to head” comparisons which could result in one unit being maintained or upgraded to offer full emergency services while the other nearby AE could be closed or offer reduced care. Such decisions are being considered in Shrewsbury and Telford; and Bedford and Milton Keynes.

Some clinicians argue that such moves to concentrate staff in two overstretched AEs into a single unit can be a sensible use of resources and will not necessarily result in a loss of capacity.

Longer journeys

But campaigners and experts warn that widespread closures will result in longer journeys to the nearest emergency units and place an unsustainable burden on remaining services.

Dr Taj Hassan, RCEM president, said that while the STPs had “admirable” ambitions they were in their present form “unworkable”. He said: “If it were to come to pass that one in six emergency departments are downgraded, the effects would be disastrous.

“Closure of any emergency department will naturally require more beds to be found elsewhere – patients do not just disappear when an option for care is removed.”

The National Health Action Party, which campaigns for improvements in health service funding and staffing, said the STPs offered a grim picture which could ultimately see the number of full AEs whittled down 70.

A spokesman said: “According to the STPs, to make the NHS affordable and sustainable, we the public must get used to longer ambulance journeys for emergency care, longer waiting times for treatment. There is a shortage of doctors and nurses. Our AEs no longer have a mid-winter crisis, they have a year-round crisis.”

Divert

At the heart of many STPs is a new strategy which will seek to divert many people from attending casualty by referring them to a range of alternative services from walk-in minor injury units (MIUs) to teams dedicated to treating people at home.

The North and Central London STP envisages an Acute Care At Home service under which patients, for an example an elderly person who has suffered a fall judged by paramedics not to require AE treatment, will be referred electronically by ambulance staff to an alternative team who will visit within 12 hours.

Clinicians agree that such schemes are desirable but question whether they will save money or function effectively. In north Essex, managers are considering plans to two out of three minor injury units while in Worcestershire last month four MIUs were closed for three days so staff could be redeployed to support struggling AEs in Worcester and Redditch.

An NHS England spokesperson said: “We do not expect significant numbers of AE changes in the years ahead, and many schemes were in fact decided on many years ago.”

The full list of the 19 hospitals facing closure

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