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Independent research for global prosperity

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Listen here to a preview of Stefan Freund's Civil War Oratorio. KBIA's Trevor Harris interviewed MU School of Music faculty member and composer Freund and the Museum of Art and Archaeology's Dr. Arthur Mehrhoff about the work and premiere happening April 24 in Columbia's Jesse Auditorium.
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Mar 25, 2014
Janet Macoska

Concert alert : Jim Brickman is coming to Columbia's Jesse Auditorium Monday, March 31. The adult contemporary star talked with KBIA's Trevor Harris recently about Brickman's training, his career and his genre-spanning collaborations.

Concert alert
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Listen here to the recent KBIA interview with Jim Brickman. He performs Monday, March 31 in Jesse Auditorium.
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Mar 17, 2014
Facebook/Odyssey Chamber Music Series

Settle in to listen to an hour of classical music on the radio and you'll mostly hear the works of male composers. It isn't that women do not compose in the classical genre, so why don't we hear them more often? KBIA's Ariel Morrision recently asked two local women what's behind the gender imbalance in classical compositions.

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Listen to Thinking Out Loud about the hidden history of classical music's female composers.
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Mar 12, 2014
Credit Lisa-Marie Mazzucco

Rare violins, finding a balance, and revisiting a Baroque masterpiece filled this week's High Quality Cheap Price Best Sale Cheap Price Frame Denim denim mini skirt j6FySpiPvF
. KBIA's Trevor Harris interviewed violinist Anne Akiko Meyers about her new release featuring Antonio Vivaldi 's The Four Seasons .

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13:10
Listen to the KBIA interview with classical violinist Anne Akiko Meyers.
By Trevor Harris Feb 16, 2014
AlisaWeilerstein.com

KBIA's CD of the Week this week is the new release from cellist Alisa Weilerstein . The January 2014 Decca issue pairs Weilerstein with the Czech Philharmonic Orchestra for performances of works written by Czech Antonin Dvorak during a period the composer spent in the United States .

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A look back at the year in aviation

Delta Air Lines ( ) cut its full year earnings outlook Thursday, a day after American Airlines ( ) warned that its costs and sales would be lower than expected last quarter. The culprit: Delta's fuel cost $654 million more in the second quarter than a year ago, and American said the increase in its fuel costs would be about $50 million more than it had expected.

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Higher oil prices lifted the average price of Delta's jet fuel by 39% during the spring. Prices are expected to continue to climb another 6% this quarter.

To avoid a massive dent in earnings, airlines are all doing what they can to hold the line on spending on non-fuel items, including capital spending. Lower profits would also mean smaller profit sharing bonuses for employees

Strong demand for air travel is lifting fares , which has helped offset some fuel costs. A key measure of Delta's fares was up 4.6% in the just completed quarter. Delta said it expects a similar increase in third quarter.

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Cirrito, J. R., Yamada, K. A., Finn, M. B., Sloviter, R. S., Bales, K. R., May, P. C., Schoepp, D. D., Paul, S. M., Mennerick, S. and Holtzman, D. M.
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Table 1

Overview of meta-analyses of the prognostic role of the neutrophil-to-lymphocyte ratio (NLR) in solid tumours

Abbreviations: neutrophil-to-lymphocyte ratio, Disease-free survival/Recurrence-free survival, Progression-free survival, Overall survival, Event-free survival, Odds ratio

Not only elevated numbers of neutrophils in peripheral blood as reflected by NLR are of prognostic relevance, but also their presence in the tumor can be associated with clinical outcome. The expression of neutrophils in the tumor has been linked with detrimental outcome in some indications like in renal cell carcinoma, head and neck cancer or esophageal carcinoma [ 6 , 32 , 33 ]; whereas in other indications it has been associated with better survival [ 34 , 35 ]. In this context, it should be noted that what mainly impact the worse outcome is the presence of inflammation within the tumor, and the assessment of neutrophils is an indirect measure of this and can vary among tumor types.

Table 2

List of compounds and targets that are currently in clinical development

Strategies explored to inhibit neutrophils include the inhibition of CXC receptors like CXCR2 that are associated with the migration of neutrophils to tumor areas. CXCR1 and CXCR2 inhibitors are currently in clinical development in cancer [ 38 , 39 ]. Inhibition of the IL-23 and IL-17 axis is another approach, as IL-17 and IL-23 stimulate expansion of neutrophils mediated by G-CSF (Fig. 1b ) [ Le Tricot Perugia punch hole knit cardigan Sale Pick A Best Buy Cheap Hot Sale Sale Popular Buy Cheap Finishline SF3IVie
]. However this approach has not reached yet the oncology field, but drugs targeting these cytokines are approved for the treatment of other medical conditions like psoriasis [ 41 , 42 ].

Another tactic is to directly inhibit G-CSF and therefore decrease the amount of neutrophils, strategy that has shown efficacy in preclinical models [ 43 ]. Agents against this target are currently in its early stage of clinical development in cancer [ 44 ]. However, it is unclear if the inhibition of G-CSF and subsequent reduction of neutrophils can have an impact in patient infections, mainly in those under treatment with chemotherapy. Recently, preclinical studies have shown that neutrophil Alox5 inhibition can also decrease metastatic lung dissemination (Fig. 1b ) [ 45 ].

There are many areas of uncertainty regarding the evaluation of neutrophils as a prognostic marker or in the development of compounds against neutrophils.

Although the NLR is considered as an easy, inexpensive and reproducible biomarker associated with clinical outcome for the majority of tumors some questions remain to be resolved. For instance, the identification of adequate cut-offs, or longitudinal evaluations over a treatment period of time could add more accurate information. Indeed, modifications over time can inform about treatment efficacy. Similarly, comparison of this ratio with the expression of cytokines in blood or the evaluation of neutrophil expression in tumors could help to improve its prognostic or predictive value.

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